Sensitivity of Mycobacterium leprae to Low Levels of 4,4-Diaminodiphenyl Sulfone.

Sensitivity of Mycobacterium leprae to Low Levels of 4,4-Diaminodiphenyl Sulfone.

Summary 1. The activity against M yco-bacterium leprae of 4,4-diaminodiphenyl sul-fone (DDS) was tested in mice by feeding a series of diets containing the drug in concentrations ranging from 0.03 to 0.00001%. Multiplication of M. leprae was completely suppressed at all levels. 2. The lowest DDS int...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1966-07, Vol.122 (3), p.893-896
Hauptverfasser: Shepard, Charles C., McRae, Dorothy H., Habas, Janet A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dapsone - pharmacology
Humans
Leprosy - drug therapy
Leprosy - prevention & control
Mice
Mycobacterium leprae - drug effects
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Zusammenfassung:Summary 1. The activity against M yco-bacterium leprae of 4,4-diaminodiphenyl sul-fone (DDS) was tested in mice by feeding a series of diets containing the drug in concentrations ranging from 0.03 to 0.00001%. Multiplication of M. leprae was completely suppressed at all levels. 2. The lowest DDS intake was a hundred times less that the least amount required to produce chemically detectable amounts in the blood (0.2 to 0.3 μg/ml).
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-122-31282