Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.
Summary 5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA....
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1966-07, Vol.122 (3), p.890-893 |
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| container_end_page | 893 |
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| container_issue | 3 |
| container_start_page | 890 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 122 |
| creator | Davis, Virginia E. Cashaw, Jesse L. Huff, James A. Brown, Harold |
| description | Summary
5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA. These data show that 5-HTOH is a 5-HT metabolite in man as well as in animals. |
| doi_str_mv | 10.3181/00379727-122-31281 |
| format | Article |
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5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA. These data show that 5-HTOH is a 5-HT metabolite in man as well as in animals.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-122-31281</identifier><identifier>PMID: 5918970</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Carcinoid Tumor - urine ; Chromatography, Thin Layer ; Glucuronates - urine ; Humans ; Indoles - metabolism ; Serotonin - metabolism ; Serotonin - urine ; Sulfates - urine</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1966-07, Vol.122 (3), p.890-893</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-11f516dfab3e8a39240d8650188b8848852ea4b72d0868de7e082b4cde1246ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5918970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Virginia E.</creatorcontrib><creatorcontrib>Cashaw, Jesse L.</creatorcontrib><creatorcontrib>Huff, James A.</creatorcontrib><creatorcontrib>Brown, Harold</creatorcontrib><title>Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA. These data show that 5-HTOH is a 5-HT metabolite in man as well as in animals.</description><subject>Carcinoid Tumor - urine</subject><subject>Chromatography, Thin Layer</subject><subject>Glucuronates - urine</subject><subject>Humans</subject><subject>Indoles - metabolism</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - urine</subject><subject>Sulfates - urine</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRaq3-AUHIydu2-5FNJkcpWgsVD-p52SQTTUmzcXcD5t-b2urR0zDM874wDyHXnM0lB75gTKZZKlLKhaCSC-AnZMqVVFQmWXZKpnuA7olzcuH9ljGuUpFMyERlHLKUTclqXWIb6qouTKhtG9kqUvRxKJ39GoIbumC7D9tExkcmekFng23rNnrCYHLb1AGj9biZdn5JzirTeLw6zhl5e7h_XT7SzfNqvbzb0EJKCJTzSvGkrEwuEYzMRMxKSBTjADlADKAEmjhPRckggRJTZCDyuCiRizjBQs7I7aG3c_azRx_0rvYFNo1p0fZeQyxkEisYQXEAC2e9d1jpztU74wbNmd7b07_29GhP_9gbQzfH9j7fYfkXOeoa74vD3Zt31Fvbu3Z89r_GbwuMdug</recordid><startdate>196607</startdate><enddate>196607</enddate><creator>Davis, Virginia E.</creator><creator>Cashaw, Jesse L.</creator><creator>Huff, James A.</creator><creator>Brown, Harold</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196607</creationdate><title>Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.</title><author>Davis, Virginia E. ; Cashaw, Jesse L. ; Huff, James A. ; Brown, Harold</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-11f516dfab3e8a39240d8650188b8848852ea4b72d0868de7e082b4cde1246ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Carcinoid Tumor - urine</topic><topic>Chromatography, Thin Layer</topic><topic>Glucuronates - urine</topic><topic>Humans</topic><topic>Indoles - metabolism</topic><topic>Serotonin - metabolism</topic><topic>Serotonin - urine</topic><topic>Sulfates - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Virginia E.</creatorcontrib><creatorcontrib>Cashaw, Jesse L.</creatorcontrib><creatorcontrib>Huff, James A.</creatorcontrib><creatorcontrib>Brown, Harold</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Virginia E.</au><au>Cashaw, Jesse L.</au><au>Huff, James A.</au><au>Brown, Harold</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1966-07</date><risdate>1966</risdate><volume>122</volume><issue>3</issue><spage>890</spage><epage>893</epage><pages>890-893</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA. These data show that 5-HTOH is a 5-HT metabolite in man as well as in animals.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5918970</pmid><doi>10.3181/00379727-122-31281</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1966-07, Vol.122 (3), p.890-893 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Carcinoid Tumor - urine Chromatography, Thin Layer Glucuronates - urine Humans Indoles - metabolism Serotonin - metabolism Serotonin - urine Sulfates - urine |
| title | Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man. |
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