Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.

Identification of 5-Hydroxytryptophol as a Serotonin Metabolite In Man.

Summary 5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA....

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1966-07, Vol.122 (3), p.890-893
Hauptverfasser: Davis, Virginia E., Cashaw, Jesse L., Huff, James A., Brown, Harold
Format: Artikel
Sprache:eng
Schlagworte:
Carcinoid Tumor - urine
Chromatography, Thin Layer
Glucuronates - urine
Humans
Indoles - metabolism
Serotonin - metabolism
Serotonin - urine
Sulfates - urine
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Zusammenfassung:Summary 5-Hydroxytryptophol has been isolated, identified, and measured in urine of subjects with carcinoid tumors. In the urine of normal subjects and of patients with carcinoid tumors who ingested 5-HT-C14, 2.3% of the excreted C14 was attributable to 5-HTOH and its conjugates and 82.3% to 5-HIAA. These data show that 5-HTOH is a 5-HT metabolite in man as well as in animals.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-122-31281