Uricolytic Enzymes in Liver of the Dipnoan Protopterus aethiopicus

Uricolytic Enzymes in Liver of the Dipnoan Protopterus aethiopicus

The enzymes uricase, allantoinase, and allantoicase have been measured in liver preparations of the African lungfish Protopterus aethiopicus. The levels for these enzymes in lungfish liver suggest that the amount of urea formed in vivo in Protopterus via a uricolytic pathway may be greater than that...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1966-09, Vol.153 (3744), p.1653-1654
Hauptverfasser: Brown, G. W., James, Jesse, Henderson, Ralph J., Thomas, Walter N., Robinson, Robert O., Thompson, Arthur L., Brown, Earlene, Brown, Susan G.
Format: Artikel
Sprache:eng
Schlagworte:
Ammonia
Aquatic habitats
Chordata, Nonvertebrate
Enzymes
Liver
Liver - enzymology
Liver - metabolism
Purines
Purines - metabolism
Urate Oxidase - analysis
Urea - biosynthesis
Ureohydrolases - analysis
Uric acid
Vertebrates
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Zusammenfassung:The enzymes uricase, allantoinase, and allantoicase have been measured in liver preparations of the African lungfish Protopterus aethiopicus. The levels for these enzymes in lungfish liver suggest that the amount of urea formed in vivo in Protopterus via a uricolytic pathway may be greater than that derived via the ornithine-urea cycle. The operation of a "purine cycle" in lungfish liver is proposed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.153.3744.1653