Blood Nitrite and Nitrate Concentration After Oral and Intravenous Administration of Glyceryl Trinitrate in Rabbits

Blood nitrite and nitrate concentrations were measured after oral and intravenous administration of glyceryl trinitrate at 1.0mg./Kg. in rabbits. Nitrate and nitrite blood concentrations attained peak concentrations in 90–120min. after oral administration and slowly returned to control levels. Nitrate and nitrite blood concentrations decreased slowly after intravenous administration of glyceryl trinitrate, then fell rapidly after 60min. Blood nitrate concentrations were twice the blood nitrite concentrations 60min. after either oral or intravenous administration of glyceryl trinitrate.