Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces

Phosphonomycin is a newly discovered antibiotic produced by streptomycetes. It is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms. The antibiotic is bactericidal and inhibits cell-wall synthesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-10, Vol.166 (3901), p.122-123
Hauptverfasser:	Hendlin, D., Stapley, E. O., Jackson, M., Wallick, H., Miller, A. K., Wolf, F. J., Miller, T. W., Chaiet, L., Kahan, F. M., Foltz, E. L., Woodruff, H. B., Mata, J. M., Hernandez, S., Mochales, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatases Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria - drug effects Cell Wall - drug effects Cockroaches Enzymes Infection - drug therapy Infections Insect larvae Mice Phosphatases Poisoning Streptomyces Streptomyces - metabolism Toxicity
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Beschreibung
Zusammenfassung:	Phosphonomycin is a newly discovered antibiotic produced by streptomycetes. It is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms. The antibiotic is bactericidal and inhibits cell-wall synthesis.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.166.3901.122