Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties

Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties

MYCOPHENOLIC acid (UK patent applications 43131/66 and 43132/66) emerged as a potential anti-cancer compound during routine screening tests with mould filtrates for activity against mouse fibroblasts. Our aim was to detect substances having a more specific action than general lethality: substances w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1969-08, Vol.223 (5208), p.848-850
Hauptverfasser: CARTER, S. B, FRANKLIN, T. J, JONES, D. F, LEONARD, B. J, MILLS, S. D, TURNER, R. W, TURNER, W. B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - therapeutic use
Caproates - therapeutic use
Carcinoma 256, Walker - drug therapy
Humanities and Social Sciences
letter
Lung Neoplasms - drug therapy
Mice
Mitosis - drug effects
multidisciplinary
Neoplasm Transplantation
Neoplasms, Experimental - drug therapy
Rats
Sarcoma 180 - drug therapy
Sarcoma, Yoshida - drug therapy
Science
Science (multidisciplinary)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:MYCOPHENOLIC acid (UK patent applications 43131/66 and 43132/66) emerged as a potential anti-cancer compound during routine screening tests with mould filtrates for activity against mouse fibroblasts. Our aim was to detect substances having a more specific action than general lethality: substances which, for example, inhibit cell division or interfere with the mitotic mechanism.
ISSN:0028-0836
1476-4687
DOI:10.1038/223848a0