Some Effects of Ethanol on the Disposition of Palmitate by Intact And Adrenalectomized Rats

Summary and conclusions Our experiments show that adrenalectomized rats oxidize FFA and incorporate FFA into liver lipids as well as the intact rat. In both groups of animals, ethanol increased the content of palmitate-1-C14 in liver lipids at 1 hour and decreased the amount oxidized to CO2. The most marked increase in isotope content of liver lipids occurred in the ADX rats. Among the effects of large doses of ethanol on PL classes was a marked relative increase of palmitate incorporation into the phosphatidylserine fraction of both groups and a corresponding decrease in the amount in phosphatidylcholine. Blood levels of ethanol were higher in adrenalectomized rats than in intact rats.