Effect of corticosteroid on the acidosis of prolonged cardiopulmonary bypass

Effect of corticosteroid on the acidosis of prolonged cardiopulmonary bypass

Total cardiopulmonary bypass at a flow rate of 50 ml. per kilogram of body weight per minute consistently produced metabolic acidosis in adult mongrel dogs. The acidosis was partially inhibited by pretreatment of the animals with large doses of corticosteroids. The pretreated animals showed a greate...

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Veröffentlicht in:The Journal of surgical research 1966-01, Vol.6 (8), p.354-360
Hauptverfasser: Moses, Melvin L., Camishion, Rudolph C., Tokunaga, Kouichi, Pierucci, Louis, Davies, Allen L., Nealon, Thomas F.
Format: Artikel
Sprache:eng
Schlagworte:
Acidosis - prevention & control
Animals
Blood Chemical Analysis
Blood Gas Analysis
Blood Pressure
Dogs
Heart-Lung Machine - adverse effects
Hydrocortisone - therapeutic use
In Vitro Techniques
Methylprednisolone - therapeutic use
Mortality
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Zusammenfassung:Total cardiopulmonary bypass at a flow rate of 50 ml. per kilogram of body weight per minute consistently produced metabolic acidosis in adult mongrel dogs. The acidosis was partially inhibited by pretreatment of the animals with large doses of corticosteroids. The pretreated animals showed a greater survival rate and a better postoperative clinical condition. Possible explanations for the effect of the steroids are discussed.
ISSN:0022-4804
1095-8673
DOI:10.1016/S0022-4804(66)80051-3