Growth-Hormone Deficiency in Man: An Isolated, Recessively Inherited Defect

Growth-Hormone Deficiency in Man: An Isolated, Recessively Inherited Defect

A deficiency of human growth hormone not associated with other pituitary deficiencies was observed in midgets with sexual ateliosis, a form of dwarfism inherited as an autosomal recessive trait. Body proportions, sexual development, birth weight, and postpartum lactation are normal in this syndrome.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1966-06, Vol.152 (3729), p.1635-1637
Hauptverfasser: Rimoin, David L., Merimee, Thomas J., McKusick, Victor A.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenocorticotropic Hormone - metabolism
Adult
Aged
Arginine - pharmacology
Birth Weight
Body Height
Child growth
Dwarfism
Female
Follicle Stimulating Hormone - metabolism
Genetic inheritance
Growth Hormone
Growth hormones
Human growth
Humans
In Vitro Techniques
Insulin
Insulin - pharmacology
Lactation
Male
Middle Aged
Pituitary Function Tests
Pregnancy
Puberty
Sex Characteristics
Sex hormones
Thyrotropin - metabolism
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Beschreibung
Zusammenfassung:A deficiency of human growth hormone not associated with other pituitary deficiencies was observed in midgets with sexual ateliosis, a form of dwarfism inherited as an autosomal recessive trait. Body proportions, sexual development, birth weight, and postpartum lactation are normal in this syndrome.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.152.3729.1635