Antiviral Activity of an Interferon-Inducing Synthetic Polymer
Summary A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of prote...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-06, Vol.131 (2), p.443-446 |
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| container_end_page | 446 |
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| container_issue | 2 |
| container_start_page | 443 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 131 |
| creator | Came, P. E. Lieberman, M. Pascale, A. Shimonaski, G. |
| description | Summary
A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of protection of PVS has not been completely elucidated and the possibility that it exerts multiple modes of activity cannot be excluded. |
| doi_str_mv | 10.3181/00379727-131-33897 |
| format | Article |
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A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of protection of PVS has not been completely elucidated and the possibility that it exerts multiple modes of activity cannot be excluded.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-131-33897</identifier><identifier>PMID: 5787122</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Herpesviridae - drug effects ; Interferons - analysis ; Male ; Methods ; Mice ; Orthomyxoviridae - drug effects ; Polyvinyls - pharmacology ; Vaccinia virus - drug effects ; Viral Interference ; Viruses - drug effects</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1969-06, Vol.131 (2), p.443-446</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-84ad31370af31c032938a10d8f31c9cfcc30cd0cba8585b8a6226361115391173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5787122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Came, P. E.</creatorcontrib><creatorcontrib>Lieberman, M.</creatorcontrib><creatorcontrib>Pascale, A.</creatorcontrib><creatorcontrib>Shimonaski, G.</creatorcontrib><title>Antiviral Activity of an Interferon-Inducing Synthetic Polymer</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of protection of PVS has not been completely elucidated and the possibility that it exerts multiple modes of activity cannot be excluded.</description><subject>Animals</subject><subject>Herpesviridae - drug effects</subject><subject>Interferons - analysis</subject><subject>Male</subject><subject>Methods</subject><subject>Mice</subject><subject>Orthomyxoviridae - drug effects</subject><subject>Polyvinyls - pharmacology</subject><subject>Vaccinia virus - drug effects</subject><subject>Viral Interference</subject><subject>Viruses - drug effects</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFLwzAQxoMoc07_AUHok29xudzapC_CGFMHAwX1OWRpOjvadCat0P_e1k0ffbo7vu8-7n6EXAO7Q5AwZQxFKriggEARZSpOyBhijCkmaXpKxoOBDo5zchHCjjGIBU9GZBQLKYDzMbmfu6b4Krwuo7kZuqaL6jzSLlq5xvrc-trRlctaU7ht9Nq55sM2hYle6rKrrL8kZ7kug7061gl5f1i-LZ7o-vlxtZivqenPaqic6QwBBdM5gmHIU5QaWCaHMTW5MchMxsxGy1jGG6kTzhNMAPpnUgCBE3J7yN37-rO1oVFVEYwtS-1s3QYlZyAZzOLeyA9G4-sQvM3V3heV9p0CpgZo6hea6qGpH2j90s0xvd1UNvtbOVLq9elBD3pr1a5uveuf_S_xG0v7c6k</recordid><startdate>196906</startdate><enddate>196906</enddate><creator>Came, P. E.</creator><creator>Lieberman, M.</creator><creator>Pascale, A.</creator><creator>Shimonaski, G.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196906</creationdate><title>Antiviral Activity of an Interferon-Inducing Synthetic Polymer</title><author>Came, P. E. ; Lieberman, M. ; Pascale, A. ; Shimonaski, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-84ad31370af31c032938a10d8f31c9cfcc30cd0cba8585b8a6226361115391173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Herpesviridae - drug effects</topic><topic>Interferons - analysis</topic><topic>Male</topic><topic>Methods</topic><topic>Mice</topic><topic>Orthomyxoviridae - drug effects</topic><topic>Polyvinyls - pharmacology</topic><topic>Vaccinia virus - drug effects</topic><topic>Viral Interference</topic><topic>Viruses - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Came, P. E.</creatorcontrib><creatorcontrib>Lieberman, M.</creatorcontrib><creatorcontrib>Pascale, A.</creatorcontrib><creatorcontrib>Shimonaski, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Came, P. E.</au><au>Lieberman, M.</au><au>Pascale, A.</au><au>Shimonaski, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral Activity of an Interferon-Inducing Synthetic Polymer</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1969-06</date><risdate>1969</risdate><volume>131</volume><issue>2</issue><spage>443</spage><epage>446</epage><pages>443-446</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of protection of PVS has not been completely elucidated and the possibility that it exerts multiple modes of activity cannot be excluded.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5787122</pmid><doi>10.3181/00379727-131-33897</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1969-06, Vol.131 (2), p.443-446 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84180145 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Herpesviridae - drug effects Interferons - analysis Male Methods Mice Orthomyxoviridae - drug effects Polyvinyls - pharmacology Vaccinia virus - drug effects Viral Interference Viruses - drug effects |
| title | Antiviral Activity of an Interferon-Inducing Synthetic Polymer |
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