Antiviral Activity of an Interferon-Inducing Synthetic Polymer

Antiviral Activity of an Interferon-Inducing Synthetic Polymer

Summary A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of prote...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-06, Vol.131 (2), p.443-446
Hauptverfasser: Came, P. E., Lieberman, M., Pascale, A., Shimonaski, G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Herpesviridae - drug effects
Interferons - analysis
Male
Methods
Mice
Orthomyxoviridae - drug effects
Polyvinyls - pharmacology
Vaccinia virus - drug effects
Viral Interference
Viruses - drug effects
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Beschreibung
Zusammenfassung:Summary A synthetic anionic polymer, polyvinyl sulfate (PVS) showed in vitro and in vivo antiviral activity. The polymer did not induce interferon in vitro in L929 or chick embryo cells but interferon could be detected in the circulation of mice treated with polyvinyl sulfate. The mechanism of protection of PVS has not been completely elucidated and the possibility that it exerts multiple modes of activity cannot be excluded.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-131-33897