Effect of Long Term Administration of Insect-Metamorphosing Substances on Higher Animals. I

Effect of Long Term Administration of Insect-Metamorphosing Substances on Higher Animals. I

Longterm feeding of insect-metamorphosing substances, ecdysterone and cyasterone, slightly increased the growth of mice without any toxicity, when administered in doses of 5-100 μg/day/animal. Daily administration of these steroids even in a dose of 5μg/animal maintained protein synthesis in liver a...

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Veröffentlicht in:YAKUGAKU ZASSHI 1969/02/25, Vol.89(2), pp.235-240
Hauptverfasser: HIKINO, HIROSHI, NABETANI, SUSUMU, NOMOTO, KYOSUKE, ARAI, TOMIO, TAKEMOTO, TSUNEMATSU, OTAKA, TADAHIKO, UCHIYAMA, MITSURU
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
Animals
Body Weight
Cholestanes - administration & dosage
Ecdysone - administration & dosage
Kidney - metabolism
Liver - metabolism
Male
Mice
Protein Biosynthesis
Time Factors
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Zusammenfassung:Longterm feeding of insect-metamorphosing substances, ecdysterone and cyasterone, slightly increased the growth of mice without any toxicity, when administered in doses of 5-100 μg/day/animal. Daily administration of these steroids even in a dose of 5μg/animal maintained protein synthesis in liver and kidney in an elevated level. Histological examinations of liver tissues after a 90 day administration revealed that metabolism of the cells was activated by ecdysterone and cyasterone.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.89.2_235