Conformational Aspects of Local Anesthetics

The syntheses of two epimers of 3-exo-(N,N-dimethylaminomethyl-2-norbornanyl)4-n-butoxybenzoate are described. The results of several assays of local anesthetic activity are discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1969-05, Vol.58 (5), p.553-556
Hauptverfasser:	Boots, Marvin R., Boots, Sharon G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-exo-(N 3-exo-(N, N-Dimethylaminomethyl-2-norbornanyl)4-n-butoxybenzoate epimers—synthesis Anesthesia, Conduction Anesthetics Anesthetics, Local - chemical synthesis Anesthetics, Local - pharmacology Anesthetics, local—conformational aspects Animals Anura Benzoates - chemical synthesis Benzoates - pharmacology Guinea Pigs Infrared Rays IR spectrophotometry-structure Lidocaine - pharmacology local-conformational aspects Magnetic Resonance Spectroscopy N-Dimethylaminomethyl-2-norbornanyl)4-n-butoxybenzoate epimers-synthesis NMR spectroscopy-structure Pharmacological screening-local anesthetics Rabbits Rats Sciatic Nerve - drug effects Spectrophotometry Stereoisomerism Ultraviolet Rays UV spectrophotometry-structure
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Beschreibung
Zusammenfassung:	The syntheses of two epimers of 3-exo-(N,N-dimethylaminomethyl-2-norbornanyl)4-n-butoxybenzoate are described. The results of several assays of local anesthetic activity are discussed.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600580505