Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents
A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase in vitro. Bipyridyl, o-phenanthroline, TPTZ (2,4,6-tripyridyl- s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. I...
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| Veröffentlicht in: | Biochemical pharmacology 1969-03, Vol.18 (3), p.587-594 |
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| container_title | Biochemical pharmacology |
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| creator | Taylor, R.J. Stubbs, C.S. Ellenbogen, Leon |
| description | A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase
in vitro. Bipyridyl,
o-phenanthroline, TPTZ (2,4,6-tripyridyl-
s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by
o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines. |
| doi_str_mv | 10.1016/0006-2952(69)90083-5 |
| format | Article |
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in vitro. Bipyridyl,
o-phenanthroline, TPTZ (2,4,6-tripyridyl-
s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by
o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(69)90083-5</identifier><identifier>PMID: 5772589</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adrenal Glands - drug effects ; Adrenal Glands - enzymology ; Animals ; Brain - drug effects ; Brain - metabolism ; Catecholamines - metabolism ; Cattle ; Chelating Agents ; Heart - drug effects ; Iron ; Male ; Mixed Function Oxygenases - antagonists & inhibitors ; Myocardium - enzymology ; Norepinephrine - metabolism ; Phenanthrolines - pharmacology ; Pteridines - pharmacology ; Pyridinium Compounds - pharmacology ; Rats ; Triazines - pharmacology ; Tritium ; Tyrosine</subject><ispartof>Biochemical pharmacology, 1969-03, Vol.18 (3), p.587-594</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fd4bf42dfb6f7e3b0a46015f3202ac1b90029fc1ca71e36b2c7d2438c005429f3</citedby><cites>FETCH-LOGICAL-c357t-fd4bf42dfb6f7e3b0a46015f3202ac1b90029fc1ca71e36b2c7d2438c005429f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006295269900835$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5772589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, R.J.</creatorcontrib><creatorcontrib>Stubbs, C.S.</creatorcontrib><creatorcontrib>Ellenbogen, Leon</creatorcontrib><title>Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase
in vitro. Bipyridyl,
o-phenanthroline, TPTZ (2,4,6-tripyridyl-
s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by
o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - enzymology</subject><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Catecholamines - metabolism</subject><subject>Cattle</subject><subject>Chelating Agents</subject><subject>Heart - drug effects</subject><subject>Iron</subject><subject>Male</subject><subject>Mixed Function Oxygenases - antagonists & inhibitors</subject><subject>Myocardium - enzymology</subject><subject>Norepinephrine - metabolism</subject><subject>Phenanthrolines - pharmacology</subject><subject>Pteridines - pharmacology</subject><subject>Pyridinium Compounds - pharmacology</subject><subject>Rats</subject><subject>Triazines - pharmacology</subject><subject>Tritium</subject><subject>Tyrosine</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EKqXwBiDlhOAQ8F-c5IKEKqBIlbiUs-XY69YoTYqdVuTtcWjVI6fd9cyuNR9C1wQ_EEzEI8ZYpLTM6J0o70uMC5ZmJ2hMipzFZ1GcovHRco4uQvgaxkKQERpleU6zohyj2aL3bXANJKve-Panr1WAxDUrV7nOtU1sk53rfJuoxuyHXZtUfaJXUKvONctELaHpwiU6s6oOcHWoE_T5-rKYztL5x9v79HmeapblXWoNryynxlbC5sAqrLjAJLOMYqo0qWIOWlpNtMoJMFFRnRvKWaExznhU2ATd7u9ufPu9hdDJtQsa6lo10G6DLDgRjOdlNPK9UceAwYOVG-_WyveSYDkAlAMOOdCRopR_AGUW124O97fVGsxx6UAs6k97HWLInQMvg3bQaDDOg-6kad3_H_wCN-F_rg</recordid><startdate>196903</startdate><enddate>196903</enddate><creator>Taylor, R.J.</creator><creator>Stubbs, C.S.</creator><creator>Ellenbogen, Leon</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196903</creationdate><title>Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents</title><author>Taylor, R.J. ; Stubbs, C.S. ; Ellenbogen, Leon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fd4bf42dfb6f7e3b0a46015f3202ac1b90029fc1ca71e36b2c7d2438c005429f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - enzymology</topic><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Catecholamines - metabolism</topic><topic>Cattle</topic><topic>Chelating Agents</topic><topic>Heart - drug effects</topic><topic>Iron</topic><topic>Male</topic><topic>Mixed Function Oxygenases - antagonists & inhibitors</topic><topic>Myocardium - enzymology</topic><topic>Norepinephrine - metabolism</topic><topic>Phenanthrolines - pharmacology</topic><topic>Pteridines - pharmacology</topic><topic>Pyridinium Compounds - pharmacology</topic><topic>Rats</topic><topic>Triazines - pharmacology</topic><topic>Tritium</topic><topic>Tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, R.J.</creatorcontrib><creatorcontrib>Stubbs, C.S.</creatorcontrib><creatorcontrib>Ellenbogen, Leon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, R.J.</au><au>Stubbs, C.S.</au><au>Ellenbogen, Leon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1969-03</date><risdate>1969</risdate><volume>18</volume><issue>3</issue><spage>587</spage><epage>594</epage><pages>587-594</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase
in vitro. Bipyridyl,
o-phenanthroline, TPTZ (2,4,6-tripyridyl-
s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by
o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>5772589</pmid><doi>10.1016/0006-2952(69)90083-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1969-03, Vol.18 (3), p.587-594 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Brain - drug effects Brain - metabolism Catecholamines - metabolism Cattle Chelating Agents Heart - drug effects Iron Male Mixed Function Oxygenases - antagonists & inhibitors Myocardium - enzymology Norepinephrine - metabolism Phenanthrolines - pharmacology Pteridines - pharmacology Pyridinium Compounds - pharmacology Rats Triazines - pharmacology Tritium Tyrosine |
| title | Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents |
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