Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents

A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase in vitro. Bipyridyl, o-phenanthroline, TPTZ (2,4,6-tripyridyl- s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. I...

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Veröffentlicht in:	Biochemical pharmacology 1969-03, Vol.18 (3), p.587-594
Hauptverfasser:	Taylor, R.J., Stubbs, C.S., Ellenbogen, Leon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Brain - drug effects Brain - metabolism Catecholamines - metabolism Cattle Chelating Agents Heart - drug effects Iron Male Mixed Function Oxygenases - antagonists & inhibitors Myocardium - enzymology Norepinephrine - metabolism Phenanthrolines - pharmacology Pteridines - pharmacology Pyridinium Compounds - pharmacology Rats Triazines - pharmacology Tritium Tyrosine
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Zusammenfassung:	A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase in vitro. Bipyridyl, o-phenanthroline, TPTZ (2,4,6-tripyridyl- s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(69)90083-5