A CLINICAL TRIAL OF ALPHA-METHYLDOPA IN ELATED STATES

A CLINICAL TRIAL OF ALPHA-METHYLDOPA IN ELATED STATES

A clinical trial of alpha-methyldopa (Aldomet) in elated states is reported. Four drug trials were conducted in three "manic" patients at dosage levels up to 6 gms. per day. No therapeutic effect was noted, although a pharmacologic effect as evidenced by a fall in blood pressure in three o...

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Veröffentlicht in:The American journal of psychiatry 1966-04, Vol.122 (10), p.1185-1188
Hauptverfasser: MOSHER, LOREN R, KLERMAN, GERALD L, GREANEY, JOSEPH F
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Bipolar Disorder - drug therapy
Clinical Trials as Topic
Humans
Hypotension
Male
Methyldopa - therapeutic use
Middle Aged
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Zusammenfassung:A clinical trial of alpha-methyldopa (Aldomet) in elated states is reported. Four drug trials were conducted in three "manic" patients at dosage levels up to 6 gms. per day. No therapeutic effect was noted, although a pharmacologic effect as evidenced by a fall in blood pressure in three of four trials was noted. However, further studies with this compound in psychiatric patients are indicated before final conclusions can be drawn.
ISSN:0002-953X
1535-7228
DOI:10.1176/ajp.122.10.1185