Puromycin Analogs: Action of Adrenocorticotropic Hormone and the Role of Glycogen

The effect of the injection into rats of analogs of puromycin, 6-dimethylaminopurine, and the aminonucleoside of puromycin on the stimulation of steroidogenesis by adrenocorticotropic hormone was compared with that of puromycin and cycloheximide. This stimulation was blocked only by the antibiotics,...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1966-06, Vol.152 (3727), p.1386-1388
Hauptverfasser:	Garren, Leonard D., Davis, Warren W., Crocco, R. Michael, Ney, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - biosynthesis Adrenal glands Adrenal Glands - metabolism Adrenocorticotropic Hormone - pharmacology Animals Anti-Bacterial Agents - pharmacology Antibiotics Glycogen Glycogen - metabolism Glycogenolysis Hormones Hypophysectomy In Vitro Techniques Liver Liver - metabolism Liver glycogen Protein synthesis Puromycin - pharmacology Rats Steroidogenesis Steroids
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Zusammenfassung:	The effect of the injection into rats of analogs of puromycin, 6-dimethylaminopurine, and the aminonucleoside of puromycin on the stimulation of steroidogenesis by adrenocorticotropic hormone was compared with that of puromycin and cycloheximide. This stimulation was blocked only by the antibiotics, which also inhibited adrenal protein synthesis. Glycogenolysis is not associated with the primary mechanism of the adrenocorticotropic hormone stimulation of steroid hormone biosynthesis in rats.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.152.3727.1386