Degradation of parathion in the rat

Degradation of parathion in the rat

Examination of urinary metabolites of 32P- and 35S-parathion orally administered to rats confirmed that initial metabolism of parathion involved activation to paraoxon and degradation to diethyl phosphorothioic acid. Sulfur detached in the activation reaction was excreted as inorganic sulfate. Exper...

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Veröffentlicht in:Biochemical pharmacology 1969-05, Vol.18 (5), p.1103-1114
Hauptverfasser: Nakatsugawa, T., Tolman, N.M., Dahm, P.A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromatography, Gel
Chromatography, Ion Exchange
Glutathione - metabolism
Liver - analysis
Liver - enzymology
Liver - metabolism
Male
Microsomes - enzymology
Parathion - analysis
Parathion - metabolism
Parathion - urine
Phosphoric Acids - urine
Phosphorus Isotopes
Rats
Sulfur Isotopes
Time Factors
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Zusammenfassung:Examination of urinary metabolites of 32P- and 35S-parathion orally administered to rats confirmed that initial metabolism of parathion involved activation to paraoxon and degradation to diethyl phosphorothioic acid. Sulfur detached in the activation reaction was excreted as inorganic sulfate. Experiments in vitro with 35S-parathion indicated that the aryl-phosphate cleavage of parathion was mostly effected by liver microsomal oxidases; a minor portion was catalyzed by nonoxidative soluble enzymes requiring reduced glutathione.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(69)90114-2