Relation of Pharmacological and Behavioral Effects of a Hallucinogenic Amphetamine to Distribution in Cat Brain

The hallucinogen 2,5-dimethoxy-4-methylamphetamine, also known as STP, accumulates in specific areas of cat brains. The unchanged compound was detected in the brain for at least 6 hours, whereas its behavioral effects lasted for about 4 hours. The coincidental pharmacological and behavioral effects...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-05, Vol.164 (3883), p.1085-1087
Hauptverfasser:	Idänpään-Heikkilä, Juhana E., McIsaac, William M., Ho, Beng T., Fritchie, George E., Tansey, L. Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Behavior, Animal - drug effects Brain Chemistry - drug effects Cats Gray matter Hallucinogens Hallucinogens - pharmacology Hypothalamus Injections, Intravenous Pharmacology Phenethylamines Pupil Pupil - drug effects Radioactive decay Tritium White matter
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Beschreibung
Zusammenfassung:	The hallucinogen 2,5-dimethoxy-4-methylamphetamine, also known as STP, accumulates in specific areas of cat brains. The unchanged compound was detected in the brain for at least 6 hours, whereas its behavioral effects lasted for about 4 hours. The coincidental pharmacological and behavioral effects of the compound apparently indicate a relation between the anatomical distribution and action.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.164.3883.1085