Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse
Summary and Conclusion The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-05, Vol.131 (1), p.97-100 |
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| container_end_page | 100 |
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| container_issue | 1 |
| container_start_page | 97 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 131 |
| creator | Williams, Martin W. Williams, Charles S. Meeks, Laurence A. Gunning, Barbara E. |
| description | Summary and Conclusion
The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for up to 6 weeks resulted in only a slight decrease in tolerance, which returned to its earlier state after a very few daily doses. M99, based upon 15-min peak analgesic effects in these tests, was approximately 2000 times as potent as morphine. |
| doi_str_mv | 10.3181/00379727-131-33812 |
| format | Article |
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The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for up to 6 weeks resulted in only a slight decrease in tolerance, which returned to its earlier state after a very few daily doses. M99, based upon 15-min peak analgesic effects in these tests, was approximately 2000 times as potent as morphine.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-131-33812</identifier><identifier>PMID: 5770132</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Analgesics - pharmacology ; Animals ; Drug Tolerance ; Female ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Mice ; Morphine - pharmacology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1969-05, Vol.131 (1), p.97-100</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5770132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Martin W.</creatorcontrib><creatorcontrib>Williams, Charles S.</creatorcontrib><creatorcontrib>Meeks, Laurence A.</creatorcontrib><creatorcontrib>Gunning, Barbara E.</creatorcontrib><title>Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary and Conclusion
The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for up to 6 weeks resulted in only a slight decrease in tolerance, which returned to its earlier state after a very few daily doses. M99, based upon 15-min peak analgesic effects in these tests, was approximately 2000 times as potent as morphine.</description><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Drug Tolerance</subject><subject>Female</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Mice</subject><subject>Morphine - pharmacology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1OwzAQRi0EKqVwASSkrBAsTG1PHcfLKio_Uis2ZW25yaRNlSbFThbcgBtwP06CS1uWrEb2vO_T6BFyzdkD8IQPGQOllVCUA6cACRcnpM8lSAqx1qekvwPojjgnF96vGeNSibhHelIpxkH0STqubbVEX2bRvKnQ2TrDqG2iSdu47aqsMbqbaX3__fkV2TqPZsffso7aFYZ35_GSnBW28nh1mAPy9jiZp890-vr0ko6nNBOJbqnMGMQo4zBzKAQf5aBAgF4A10ojMsyxUFlhGdgiERIXMpegY4QQChQMyO2-d-ua9w59azalz7CqbI3hDpOMOMRCxQEUezBzjfcOC7N15ca6D8OZ2ZkzR3MmmDO_5kLo5tDeLTaY_0UOqsJ-uN97u0SzbjoXzPn_Gn8ApRd1dA</recordid><startdate>196905</startdate><enddate>196905</enddate><creator>Williams, Martin W.</creator><creator>Williams, Charles S.</creator><creator>Meeks, Laurence A.</creator><creator>Gunning, Barbara E.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196905</creationdate><title>Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse</title><author>Williams, Martin W. ; Williams, Charles S. ; Meeks, Laurence A. ; Gunning, Barbara E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-5c036e565c0d3f214d373239b31979ee0edef7cfa03af825eb5d5396e3e569b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Drug Tolerance</topic><topic>Female</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Mice</topic><topic>Morphine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Martin W.</creatorcontrib><creatorcontrib>Williams, Charles S.</creatorcontrib><creatorcontrib>Meeks, Laurence A.</creatorcontrib><creatorcontrib>Gunning, Barbara E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Martin W.</au><au>Williams, Charles S.</au><au>Meeks, Laurence A.</au><au>Gunning, Barbara E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1969-05</date><risdate>1969</risdate><volume>131</volume><issue>1</issue><spage>97</spage><epage>100</epage><pages>97-100</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary and Conclusion
The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for up to 6 weeks resulted in only a slight decrease in tolerance, which returned to its earlier state after a very few daily doses. M99, based upon 15-min peak analgesic effects in these tests, was approximately 2000 times as potent as morphine.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5770132</pmid><doi>10.3181/00379727-131-33812</doi><tpages>4</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1969-05, Vol.131 (1), p.97-100 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Analgesics - pharmacology Animals Drug Tolerance Female Injections, Intraperitoneal Injections, Subcutaneous Mice Morphine - pharmacology |
| title | Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse |
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