Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse

Analgesic Tolerance to Etorphine (M99)∗ and Morphine in the Mouse

Summary and Conclusion The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-05, Vol.131 (1), p.97-100
Hauptverfasser: Williams, Martin W., Williams, Charles S., Meeks, Laurence A., Gunning, Barbara E.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics - pharmacology
Animals
Drug Tolerance
Female
Injections, Intraperitoneal
Injections, Subcutaneous
Mice
Morphine - pharmacology
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Zusammenfassung:Summary and Conclusion The mouse given M99 or morphine exhibited an acute tolerance to the analgesic effects of both drugs. The acute tolerance was built up rapidly following a single injection of M99 or two daily injections of morphine (24 or 48 hr, respectively). Discontinuation of drug dosage for up to 6 weeks resulted in only a slight decrease in tolerance, which returned to its earlier state after a very few daily doses. M99, based upon 15-min peak analgesic effects in these tests, was approximately 2000 times as potent as morphine.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-131-33812