On the chemical distinctions between cholinesterase and cholinoreceptor

It has been claimed that it is possible to distinguish chemically acetylcholinesterase from the cholinoreceptor by means of p-chloromercuribenzoate and dithiothreitol and consequently suggested, that the enzyme and receptor are separate proteins (1). The present study showed that these two substance...

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Veröffentlicht in:	Life sciences (1973) 1969-09, Vol.8 (17), p.989-992
1. Verfasser:	Zupancic, A O
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Alcohols - pharmacology Animals Barium - antagonists & inhibitors Chloromercuribenzoates - pharmacology Cholinesterase Inhibitors Histamine H1 Antagonists - pharmacology Ileum - drug effects In Vitro Techniques Muscle, Smooth - drug effects Rabbits Receptors, Drug Sulfur
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Zusammenfassung:	It has been claimed that it is possible to distinguish chemically acetylcholinesterase from the cholinoreceptor by means of p-chloromercuribenzoate and dithiothreitol and consequently suggested, that the enzyme and receptor are separate proteins (1). The present study showed that these two substances are inadequate for this purpose, since their activity is not specific for the cholinoreceptor, but extends over a wide range of pharmacological responses.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(69)90431-7