11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids
A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.
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Veröffentlicht in: | Journal of medicinal chemistry 1977-10, Vol.20 (10), p.1299-1304 |
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container_title | Journal of medicinal chemistry |
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creator | Jones, James H Holtz, Wilbur J Bicking, John B Cragoe, Edward J Mandel, Lewis R Kuehl, Frederick A |
description | A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay. |
doi_str_mv | 10.1021/jm00220a014 |
format | Article |
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The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00220a014</identifier><identifier>PMID: 198546</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Cyclic AMP - biosynthesis ; Female ; Heptanoic Acids - chemical synthesis ; Heptanoic Acids - pharmacology ; In Vitro Techniques ; Mice ; Ovary - drug effects ; Ovary - metabolism ; Prostaglandins E - pharmacology ; Prostaglandins, Synthetic - chemical synthesis ; Prostaglandins, Synthetic - pharmacology ; Structure-Activity Relationship</subject><ispartof>Journal of medicinal chemistry, 1977-10, Vol.20 (10), p.1299-1304</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-9a3464f516d5823a682605c62761d177177d28833a0e8313150cf2d24ed4bc2c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00220a014$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00220a014$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/198546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, James H</creatorcontrib><creatorcontrib>Holtz, Wilbur J</creatorcontrib><creatorcontrib>Bicking, John B</creatorcontrib><creatorcontrib>Cragoe, Edward J</creatorcontrib><creatorcontrib>Mandel, Lewis R</creatorcontrib><creatorcontrib>Kuehl, Frederick A</creatorcontrib><title>11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.</description><subject>Animals</subject><subject>Cyclic AMP - biosynthesis</subject><subject>Female</subject><subject>Heptanoic Acids - chemical synthesis</subject><subject>Heptanoic Acids - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Mice</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Prostaglandins E - pharmacology</subject><subject>Prostaglandins, Synthetic - chemical synthesis</subject><subject>Prostaglandins, Synthetic - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDlPAzEQhS3EFY6KliIVh8DB42udMoq4BOJQQkNjGdtLNtkjrHcl8u8xBAEF0kgjzfs08-YhtAekB4TC2bQghFJiCPAV1AFBCeaK8FXU-ZxjKinbRFshTAkhDCjbQOvQV4LLDroGOAWKR95W87oKjXnNTemyMvS6vNdN8NEdHuSzRV74ZmJKH9o8rUpTZK46nvh5Y8oqs11jMxd20Fpq8uB3v_s2ero4Hw-v8O395fVwcIsNE6zBfcO45KkA6YSizEhFJRFW0kSCgySJ5ahSjBniFQMGgtiUOsq94y-WWraNDpZ7o9-31odGF1mwPo--fdUGrThAwmk_gidL0MbHQu1TPa-zwtQLDUR_5qb_5Bbp_e-17Uvh3S_7FVSU8VLOQuPff1RTz7RMWCL0-GGkyeNoPBLqRj9H_nDJGxv0tGrrMmby7-EPnYaAYg</recordid><startdate>19771001</startdate><enddate>19771001</enddate><creator>Jones, James H</creator><creator>Holtz, Wilbur J</creator><creator>Bicking, John B</creator><creator>Cragoe, Edward J</creator><creator>Mandel, Lewis R</creator><creator>Kuehl, Frederick A</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771001</creationdate><title>11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids</title><author>Jones, James H ; Holtz, Wilbur J ; Bicking, John B ; Cragoe, Edward J ; Mandel, Lewis R ; Kuehl, Frederick A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a353t-9a3464f516d5823a682605c62761d177177d28833a0e8313150cf2d24ed4bc2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Cyclic AMP - biosynthesis</topic><topic>Female</topic><topic>Heptanoic Acids - chemical synthesis</topic><topic>Heptanoic Acids - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Mice</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Prostaglandins E - pharmacology</topic><topic>Prostaglandins, Synthetic - chemical synthesis</topic><topic>Prostaglandins, Synthetic - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, James H</creatorcontrib><creatorcontrib>Holtz, Wilbur J</creatorcontrib><creatorcontrib>Bicking, John B</creatorcontrib><creatorcontrib>Cragoe, Edward J</creatorcontrib><creatorcontrib>Mandel, Lewis R</creatorcontrib><creatorcontrib>Kuehl, Frederick A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, James H</au><au>Holtz, Wilbur J</au><au>Bicking, John B</au><au>Cragoe, Edward J</au><au>Mandel, Lewis R</au><au>Kuehl, Frederick A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1977-10-01</date><risdate>1977</risdate><volume>20</volume><issue>10</issue><spage>1299</spage><epage>1304</epage><pages>1299-1304</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><abstract>A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>198546</pmid><doi>10.1021/jm00220a014</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Cyclic AMP - biosynthesis Female Heptanoic Acids - chemical synthesis Heptanoic Acids - pharmacology In Vitro Techniques Mice Ovary - drug effects Ovary - metabolism Prostaglandins E - pharmacology Prostaglandins, Synthetic - chemical synthesis Prostaglandins, Synthetic - pharmacology Structure-Activity Relationship |
title | 11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids |
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