11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids

A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1977-10, Vol.20 (10), p.1299-1304
Hauptverfasser:	Jones, James H, Holtz, Wilbur J, Bicking, John B, Cragoe, Edward J, Mandel, Lewis R, Kuehl, Frederick A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic AMP - biosynthesis Female Heptanoic Acids - chemical synthesis Heptanoic Acids - pharmacology In Vitro Techniques Mice Ovary - drug effects Ovary - metabolism Prostaglandins E - pharmacology Prostaglandins, Synthetic - chemical synthesis Prostaglandins, Synthetic - pharmacology Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00220a014