2-(2-Aminoethylamino)-1,2-diphenylethanol derivatives, a new class of topical antiinflammatory agents

2-(2-Aminoethylamino)-1,2-diphenylethanol derivatives, a new class of topical antiinflammatory agents

A number of analogues and derivatives of the title compound were synthesized and evaluated in a new test procedure used to detect topical antiinflammatory activity. Some general comments regarding observation on the structure-activity relationship of these compounds are made.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of medicinal chemistry 1977-10, Vol.20 (10), p.1268-1272
Hauptverfasser: Fryer, R. Ian, Boris, Alfred, Earley, James V, Reeder, Earl
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Topical
Animals
Anti-Inflammatory Agents - chemical synthesis
Ethanol - analogs & derivatives
Granuloma - physiopathology
Inflammation - physiopathology
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - chemical synthesis
Phenylethyl Alcohol - pharmacology
Rats
Structure-Activity Relationship
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Beschreibung
Zusammenfassung:A number of analogues and derivatives of the title compound were synthesized and evaluated in a new test procedure used to detect topical antiinflammatory activity. Some general comments regarding observation on the structure-activity relationship of these compounds are made.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00220a008