Normal immunologic reactivity in patients with the lymphoma mycosis fungoides

Patients having the lymphoma, mycosis fungoides, make circulating antibodies to parenterally administered antigens in all stages of the illness. The titers are normal or slightly reduced in these patients. There is little, if any, alteration of delayed hypersensitivity responses in patients with mycosis fungoides. Serum immunoglobulin G levels are normal in patients with mycosis fungoides whereas the immunoglobulin A levels are elevated markedly. Serum immunoglobulin M levels are within normal limits. Possible reasons for these phenomena are discussed.