Effects of Epicardial Perfusion with Hydrogen Peroxide for Ischemic Myocardium

Effects of epicardial perfusion using dilute hydrogen peroxide for the ischemic myocardium were studied. Rabbits with ligated coronary arteries were used for this experiment. Following conclusions were obtained from this experiment. 1) Preventable effect for the onset of ventricular fibrillation was recognized with H2O2 perfusion. 2) Effectiveness for the cardiac resuscitation in situation of ventricular fibrillation was observed during H2O2 application. 3) Ischemic changes in ECG were improved after the perfusion. 4) Shock due to myocardial ischemia was improved by perfusion and nearly normal arterial pressure maintained during the H2O2 perfusion. 5) Myocardial oxygen tension increased immediately after the perfusion started. 6) Decreased M-Nade oxidase within myocardium was sustained after the H2O2 application. 7) Application of dilute hydrogen peroxide, in the form of epicardial perfusion, may prove to be useful for the ischemic myocardium.