Accumulation of ergosta 8,14 dien 3beta ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

Accumulation of ergosta 8,14 dien 3beta ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-...

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Veröffentlicht in:Lipids 1977-08, Vol.12 (8), p.666-668
Hauptverfasser: Hays, P.R, Parks, L.W, Pierce, H.D. Jr, Oehlschlager, A.C
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal Agents
Azasteroids - pharmacology
Ergosterol - analogs & derivatives
Ergosterol - metabolism
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - metabolism
Steroids, Heterocyclic - pharmacology
yeasts
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container_end_page 668
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container_title Lipids
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creator Hays, P.R
Parks, L.W
Pierce, H.D. Jr
Oehlschlager, A.C
description 15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3beta-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the delta14 sterol reductase.
doi_str_mv 10.1007/BF02533762
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subjects Antifungal Agents
Azasteroids - pharmacology
Ergosterol - analogs & derivatives
Ergosterol - metabolism
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - metabolism
Steroids, Heterocyclic - pharmacology
yeasts
title Accumulation of ergosta 8,14 dien 3beta ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent
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