Accumulation of ergosta 8,14 dien 3beta ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent

15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-...

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Veröffentlicht in:	Lipids 1977-08, Vol.12 (8), p.666-668
Hauptverfasser:	Hays, P.R, Parks, L.W, Pierce, H.D. Jr, Oehlschlager, A.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents Azasteroids - pharmacology Ergosterol - analogs & derivatives Ergosterol - metabolism Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism Steroids, Heterocyclic - pharmacology yeasts
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Zusammenfassung:	15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3beta-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the delta14 sterol reductase.
ISSN:	0024-4201 1558-9307
DOI:	10.1007/BF02533762