Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

Human HLA-A, B, C and Ia antigens were labelled by lactoperoxidase-catalysed iodination of the inner surface of lymphocyte plasma membrane and thus are transmembrane proteins. In contrast, membrane-bound human IgM and mouse IgM, IgD and Thy-1 antigen were not labelled on the inner membrane surface.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1977-09, Vol.269 (5626), p.307-311
Hauptverfasser:	Walsh, Frank S, Crumpton, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Membrane - immunology Cell Membrane - ultrastructure HLA Antigens Humanities and Social Sciences Humans Immunoglobulin D Immunoglobulin M Iodine Isoantigens Lactoperoxidase - metabolism Lymphocytes - immunology Lymphocytes - ultrastructure Membrane Proteins - immunology Mice multidisciplinary Receptors, Antigen, B-Cell Science Spleen - immunology Thymus Gland - immunology
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Beschreibung
Zusammenfassung:	Human HLA-A, B, C and Ia antigens were labelled by lactoperoxidase-catalysed iodination of the inner surface of lymphocyte plasma membrane and thus are transmembrane proteins. In contrast, membrane-bound human IgM and mouse IgM, IgD and Thy-1 antigen were not labelled on the inner membrane surface.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/269307a0