Studies on the Agglutination of Erythrocytes Treated with Human Plasmin and Some Other Enzymes

Summary The serological activity of human plasmin was compared with those of trypsin, bromelin, papain, and ficin. Human plasmin increased agglutination of erythrocytes with Rh-Hr antibodies, and to a lesser extent, with anti-Lea, anti-K, and anti-k (Cellano) antibodies. It did not decrease the agglutination of erythrocytes with anti-M, anti-N, anti-S, and anti-Fya antibodies. No increased agglutination could be observed with anti-P and anti-I antibodies. Bovine plasmin, human and bovine thrombin, and α-chymotrypsin did not alter the agglutinability of erythrocytes.