Structure of a Carbohydrate Moiety of a Unit A Glycopeptide of Calf Thyroglobulin

Structure of a Carbohydrate Moiety of a Unit A Glycopeptide of Calf Thyroglobulin

The structure of the carbohydrate moiety of a unit A glycopeptide of calf thyroglobulin was studied by glycosidase digestion, acetolysis, and methylation analysis. Based on the results, the whole structure of a unit A glycopeptide with the largest carbohydrate moiety was determined as Manαl → 2Manαl...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 1977-01, Vol.81 (6), p.1621-1631
Hauptverfasser: ITO, Setsuko, YAMASHITA, Katsuko, SPIRO, Robert G., KOBATA, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - analysis
Animals
Carbohydrates - analysis
Cattle
Chromatography, Gas
Glycopeptides
Molecular Conformation
Molecular Weight
Oligosaccharides - analysis
Thyroglobulin
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Zusammenfassung:The structure of the carbohydrate moiety of a unit A glycopeptide of calf thyroglobulin was studied by glycosidase digestion, acetolysis, and methylation analysis. Based on the results, the whole structure of a unit A glycopeptide with the largest carbohydrate moiety was determined as Manαl → 2Manαl → 6(Manαl → 2Manαl → 3) →6(Manαl → 2Manα1 → 2manα1 → 3)Manβ → 4GlcNAcβ1 → 4GlcNAC → Asn-Peptide.
ISSN:0021-924X
DOI:10.1093/oxfordjournals.jbchem.a131621