Virion-associated ribosomes are not required for the replication of Pichinde virus

Virion-associated ribosomes are not required for the replication of Pichinde virus

Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperatur...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1977-08, Vol.81 (1), p.174-176
Hauptverfasser: Leung, Wai-Choi, Rawls, William E.
Format: Artikel
Sprache:eng
Schlagworte:
Arenaviruses, New World - growth & development
Arenaviruses, New World - metabolism
Cell Line
Mutation
Ribosomes - metabolism
RNA Viruses - growth & development
Temperature
Viral Proteins - biosynthesis
Virus Replication
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container_title Virology (New York, N.Y.)
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creator Leung, Wai-Choi
Rawls, William E.
description Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperature-sensitive ribosomes replicated as well at the nonpermissive temperature as at the permissive temperature. The results suggest that the virion-associated ribosomes are not required for the replication of Pichinde virus.
doi_str_mv 10.1016/0042-6822(77)90070-8
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source MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals
subjects Arenaviruses, New World - growth & development
Arenaviruses, New World - metabolism
Cell Line
Mutation
Ribosomes - metabolism
RNA Viruses - growth & development
Temperature
Viral Proteins - biosynthesis
Virus Replication
title Virion-associated ribosomes are not required for the replication of Pichinde virus
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