Virion-associated ribosomes are not required for the replication of Pichinde virus

Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperatur...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1977-08, Vol.81 (1), p.174-176
Hauptverfasser:	Leung, Wai-Choi, Rawls, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arenaviruses, New World - growth & development Arenaviruses, New World - metabolism Cell Line Mutation Ribosomes - metabolism RNA Viruses - growth & development Temperature Viral Proteins - biosynthesis Virus Replication
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Beschreibung
Zusammenfassung:	Ribosomes of host cell origin have been isolated from Pichinde virus. A cell mutant with a temperature-sensitive defect in protein synthesis and 60 S ribosomal subunits was employed to study the role of virion-associated ribosomes in the replication of Pichinde virus. Virions carrying the temperature-sensitive ribosomes replicated as well at the nonpermissive temperature as at the permissive temperature. The results suggest that the virion-associated ribosomes are not required for the replication of Pichinde virus.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/0042-6822(77)90070-8