Domino N−H/C−H Bond Activation: Copper-Catalyzed Synthesis of Nitrogen-Bridgehead Heterocycles Using Azoles and 1,4-Dihalo-1,3-dienes

Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N−H bond and its adjacent C−H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2011-01, Vol.13 (2), p.228-231
Hauptverfasser:	Liao, Qian, Zhang, Liyun, Li, Shutao, Xi, Chanjuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoles - chemical synthesis Azoles - chemistry Catalysis Combinatorial Chemistry Techniques Copper - chemistry Cyclization Heterocyclic Compounds, 2-Ring - chemical synthesis Heterocyclic Compounds, 2-Ring - chemistry Molecular Structure Polyenes - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N−H bond and its adjacent C−H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol1026365