Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and...

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Veröffentlicht in:Organic letters 2011-01, Vol.13 (2), p.280-283
Hauptverfasser: Zhang, Yun, Jamison, Timothy F, Patel, Sejal, Mainolfi, Nello
Format: Artikel
Sprache:eng
Schlagworte:
Benzene Derivatives - chemical synthesis
Benzene Derivatives - chemistry
Chemistry, Organic - instrumentation
Chemistry, Organic - methods
Combinatorial Chemistry Techniques
Copper - chemistry
Decarboxylation
Indicators and Reagents
Molecular Structure
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Zusammenfassung:A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1026848