Experimental Model of Combined Pain and Depression Status in Rats

Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.479-484
Hauptverfasser:	Krupina, N. A, Khlebnikova, N. N, Orlova, I. N, Grafova, V. N, Smirnova, V. S, Rodina, V. I, Kukushkin, M. L, Kryzhanovsky, G. N
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animal behavior Animals Anxiety - etiology Axotomy Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Depression - chemically induced Depression, Mental depressive syndrome Drinking Behavior - drug effects Internal Medicine Laboratory Medicine Male Methods Models, Animal Motor Activity - drug effects neurogenic pain syndrome Pain Pathology Rats Rats, Wistar Sciatic Neuropathy - complications
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Zusammenfassung:	Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic pain syndrome augmented by some parameters the depressive symptoms and provoked manifestation of signs of depressive behavior in animals treated with saline.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0975-3