Physiologically Active Substances from Marine Sponges IV: Heterocyclic Compounds

Several guanidine compounds were synthesized by the reaction of acid chlorides of thiophene and furan with guanidines. Some of these compounds showed antibiotic and cytotoxic activities. Series of pyrrole compounds were synthesized and found to have significant antibiotic activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1977-07, Vol.66 (7), p.1052-1054
Hauptverfasser:	Chib, Joginder S., Stempien, Martin F., Cecil, Jack T., Ruggieri, George D., Nigrelli, Ross F.
Format:	Artikel
Sprache:	eng
Schlagworte:	and thiophenes evaluated and thiophenes evaluated for antibacterial and cytotoxic activity and thiophenes synthesized Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial activity-various pyrroles Antibacterial activity—various pyrroles, furans, and thiophenes evaluated Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - pharmacology Cell Survival - drug effects Cytotoxic activity-various furans and thiophenes evaluated Escherichia coli - drug effects evaluated for antibacterial activity evaluated for antibacterial and cytotoxic activity Furans Furans - chemical synthesis Furans - pharmacology Furans, various—synthesized, evaluated for antibacterial and cytotoxic activity Heterocycles-various pyrroles Heterocycles—various pyrroles, furans, and thiophenes synthesized, evaluated for antibacterial and cytotoxic activity Heterocyclic Compounds - chemical synthesis Porifera Pyrroles Pyrroles - chemical synthesis Pyrroles - pharmacology Pyrroles, various—synthesized, evaluated for antibacterial activity Structure-activity relationships-various pyrroles Structure-activity relationships—various pyrroles, furans, and thiophenes evaluated for antibacterial and cytotoxic activity Thiophenes Thiophenes - chemical synthesis Thiophenes - pharmacology Thiophenes, various—synthesized, evaluated for antibacterial and cytotoxic activity various-synthesized
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Beschreibung
Zusammenfassung:	Several guanidine compounds were synthesized by the reaction of acid chlorides of thiophene and furan with guanidines. Some of these compounds showed antibiotic and cytotoxic activities. Series of pyrrole compounds were synthesized and found to have significant antibiotic activity.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660743