Anthelmintic 2-Arylhydrazino- and 2-Arylazo-2-thiazolines

Some 2-arylhydrazino- and 2-arylazo-2-thiazolines were synthesized for anthelmintic testing. The most potent compound, 2-(o-tolylazo)-2-thiazoline, was orally effective in sheep against a broad range of helminths.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1977-08, Vol.66 (8), p.1150-1153
Hauptverfasser:	Wu, M.T., Waksmunski, F.S., Hoff, D.R., Fisher, M.H., Egerton, J.R., Patchett, A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintic activity-evaluated in various substituted thiazolines in sheep Anthelmintics - chemical synthesis Anthelmintics - therapeutic use evaluated for anthelmintic activity in sheep Helminthiasis - drug therapy Methods Sheep Structure-Activity Relationship Structure-activity relationships-various substituted thiazolines evaluated for anthelmintic activity in sheep substituted-synthesized Thiazoles - chemical synthesis Thiazoles - pharmacology Thiazoles - therapeutic use Thiazolines Thiazolines substituted—synthesized, evaluated for anthelmintic activity in sheep
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Beschreibung
Zusammenfassung:	Some 2-arylhydrazino- and 2-arylazo-2-thiazolines were synthesized for anthelmintic testing. The most potent compound, 2-(o-tolylazo)-2-thiazoline, was orally effective in sheep against a broad range of helminths.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660826