Further Evidence of a High Degree of Genetic Homology Between H. influenzae and H. aegyptius.

Summary DNA-mediated transformation to novobiocin resistance has been conferred in sensitive H. aegyptius populations. A comparison of the frequency of this event induced by DNA of heterologous source (resistant Rd H. influenzae) and by DNA of homologous source (resistant H. aegyptius) supports the earlier report(3) which suggested a high degree of genetic homology between H. aegyptius and H. influenzae. The data suggest that a genetic factor (s) inherent in the receptor population influences the level of novobiocin resistance conferred by a given DNA. The genetic factors controlling streptomycin and novobiocin resistance have been demonstrated to be linked in H. aegyptius.