Induction of Suppressor T Cells in Systemic Lupus Erythematosus by Thymosin and Cultured Thymic Epithelium

Induction of Suppressor T Cells in Systemic Lupus Erythematosus by Thymosin and Cultured Thymic Epithelium

Patients with systemic lupus erythematosus lacked suppressor T cell function. Suppressor cell activity was induced in cells from many of these patients by incubation with thymosin or cultured thymic epithelium. These results suggest that thymic manipulation may be a useful therapeutic modality in th...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1977-09, Vol.197 (4307), p.999-1001
Hauptverfasser: Horowitz, Sheldon, Borcherding, Wayne, Moorthy, A. Vishnu, Chesney, Russell, Schulte-Wissermann, Hermann, Hong, Richard, Goldstein, Allan
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
B lymphocytes
Blood cells
Concanavalin A - pharmacology
Culture Techniques
Cultured cells
Epithelial cells
Epithelium
Epithelium - immunology
Female
Humans
Immunotherapy
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Male
Middle Aged
Phagocytosis
Photoreceptors
Retinal pigments
Systemic lupus erythematosus
T lymphocytes
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Thymosin - pharmacology
Thymus Gland - immunology
Thymus Hormones - pharmacology
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Beschreibung
Zusammenfassung:Patients with systemic lupus erythematosus lacked suppressor T cell function. Suppressor cell activity was induced in cells from many of these patients by incubation with thymosin or cultured thymic epithelium. These results suggest that thymic manipulation may be a useful therapeutic modality in this disease.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.302032