Glucocorticoid in Inflammatory Proliferative Skin Disease Reduces Arachidonic and Hydroxyeicosatetraenoic Acids

Glucocorticoid in Inflammatory Proliferative Skin Disease Reduces Arachidonic and Hydroxyeicosatetraenoic Acids

Psoriasis is a prototype of several common, glucocorticoid responsive, inflammatory proliferative skin diseases. Within 28 hours, glucocorticoid reduced the increased concentration of free arachidonic acid in diseased tissue. This reduction was observed prior to visible improvement of disease and ma...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1977-09, Vol.197 (4307), p.994-996
Hauptverfasser: Hammarström, Sven, Hamberg, Mats, Duell, Elizabeth A., Stawiski, Marek A., Anderson, Thomas F., Voorhees, John J.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Arachidonic Acids - metabolism
Betamethasone - analogs & derivatives
Betamethasone - therapeutic use
Cream
Epidermis
Female
Glucocorticoids
Glucocorticoids - pharmacology
Hormones
Humans
Hydroxy Acids - metabolism
Lesions
Male
Mitochondria
Nonesterified fatty acids
Psoriasis
Psoriasis - drug therapy
Psoriasis - metabolism
Psoriasis - physiopathology
Skin diseases
Vehicles
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Zusammenfassung:Psoriasis is a prototype of several common, glucocorticoid responsive, inflammatory proliferative skin diseases. Within 28 hours, glucocorticoid reduced the increased concentration of free arachidonic acid in diseased tissue. This reduction was observed prior to visible improvement of disease and may be an important molecular mechanism for the therapeutic efficacy of glucocorticoids in psoriasis and similar inflammatory diseases.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.887938