New Synthesis of 1,4,2-Dioxazoles and Their Pharmacological Properties

A series of 3-substituted 5-methoxycarbonyl-5-methoxy-carbonylmethyl-1,4,2-dioxazoles was prepared by addition of hydroxamic acids to acetylene esters. Eleven of these previously unknown compounds were submitted to general pharmacological screening, and several displayed modest CNS depressant activi...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-06, Vol.66 (6), p.772-775
Hauptverfasser:	Heindel, Ned D., Fives, William P., Carrano, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4,2-Dioxazoles substituted—synthesis, general pharmacological screening 2-Dioxazoles 2-dioxazoles screened Aggression - drug effects Animals Anti-Inflammatory Agents, Non-Steroidal Anticonvulsants Cats CNS activity-substituted 1 CNS activity—substituted 1,4,2-dioxazoles screened Female general pharmacological screening Hemodynamics - drug effects Humans Male Mice Oxazoles - chemical synthesis Oxazoles - pharmacology Postural Balance - drug effects Rats Structure-activity relationships-substituted 1 Structure-activity relationships—substituted 1,4,2-dioxazoles general pharmacological screening substituted-synthesis Time Factors
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Zusammenfassung:	A series of 3-substituted 5-methoxycarbonyl-5-methoxy-carbonylmethyl-1,4,2-dioxazoles was prepared by addition of hydroxamic acids to acetylene esters. Eleven of these previously unknown compounds were submitted to general pharmacological screening, and several displayed modest CNS depressant activity.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660606