The human PGM-2 and its chromosomal localization in man-mouse hybrids

A detailed procedure is described for a rapid detection of phosphoglucomutase-2(=phosphopentomutase;PGM-2) on Cellogel following electrophoresis of extracts of human red blood cells and other tissues, including cultured fibroblasts and various types of primate-rodent somatic hybrid cells. The presen...

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Veröffentlicht in:	Human genetics 1977-01, Vol.37 (3), p.271-278
Hauptverfasser:	Wijnen, L M, Grzeschik, K H, Pearson, P L, Meera Khan, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosome Mapping Chromosomes, Human, 4-5 Fibroblasts - enzymology Humans Hybrid Cells - enzymology Lymphocytes - enzymology Mice Phosphoglucomutase - analysis
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Beschreibung
Zusammenfassung:	A detailed procedure is described for a rapid detection of phosphoglucomutase-2(=phosphopentomutase;PGM-2) on Cellogel following electrophoresis of extracts of human red blood cells and other tissues, including cultured fibroblasts and various types of primate-rodent somatic hybrid cells. The present study indicated that there is only one locus for phosphopentomutase in man. The data from a selected panel of 20 independent clones of man-mouse somatic cell hybrids, investigated for the presence of human chromosomes and for the presence or absence of human PGM-2 favored the assignment of the human PGM-2 locus to chromosome 4.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00393608