ATP-ase as an in_vitro Inhibitor of Surface Factor in the Blood-Clotting Mechanism.

ATP-ase as an in_vitro Inhibitor of Surface Factor in the Blood-Clotting Mechanism.

Summary As little as 5 μg/ml ATP-ase, at pH 7.0, shows a significant inhibitory effect on surface factor (SF or activation product) in vitro. ATP-ase does not inhibit thrombin, tissue thromboplastin, thrombokinase, trypsin, stypven, factors IX, VIII, × or V. The specific anti-SF effect of ATP-ase ca...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-03, Vol.118 (3), p.647-649
Hauptverfasser: Iatridis, Panayotis G., Ferguson, John H.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphatases
Adenosine Triphosphate
Blood Coagulation
Chemical Phenomena
Chemistry
Factor IX
Factor V
Factor VIII
Factor X
Humans
Old Medline
Thrombin
Thromboplastin
Trypsin
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Zusammenfassung:Summary As little as 5 μg/ml ATP-ase, at pH 7.0, shows a significant inhibitory effect on surface factor (SF or activation product) in vitro. ATP-ase does not inhibit thrombin, tissue thromboplastin, thrombokinase, trypsin, stypven, factors IX, VIII, × or V. The specific anti-SF effect of ATP-ase cannot be related to ATP or ADP. It may be significant in vivo, since platelets are a source of ATP-ase (thrombosthenine), and active SF is present in the platelet plasmatic atmosphere.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-118-29928