Discrimination of suppressor T cells of humoral and cell-mediated immunity by anti-Ly and anti-Ia sera

Discrimination of suppressor T cells of humoral and cell-mediated immunity by anti-Ly and anti-Ia sera

Evidence is presented which demonstrates that the T lymphocytes which suppress humoral and cell-mediated immunity in CBA/H mice differ in the cell surface structures they express. The suppressor T cells of delayed-type hypersensitivity are Ly-1 +, Ly-2 − and Ia −, whereas the suppressor T cells of a...

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Veröffentlicht in:Cellular immunology 1977-06, Vol.31 (2), p.364-369
Hauptverfasser: Ramshaw, Ian A., McKenzie, Ian F.C., Bretscher, Peter A., Parish, Christopher R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibody Formation
Female
Histocompatibility Antigens
Hypersensitivity, Delayed
Immunosuppression
Mice
Mice, Inbred CBA
Phenotype
Spleen - cytology
Surface Properties
T-Lymphocytes - immunology
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Zusammenfassung:Evidence is presented which demonstrates that the T lymphocytes which suppress humoral and cell-mediated immunity in CBA/H mice differ in the cell surface structures they express. The suppressor T cells of delayed-type hypersensitivity are Ly-1 +, Ly-2 − and Ia −, whereas the suppressor T cells of antibody formation are Ly-1 −, Ly-2 + and Ia +.
ISSN:0008-8749
1090-2163
DOI:10.1016/0008-8749(77)90038-7