BIOCHEMICAL STUDIES OF MYOCARDIUM AND BLOOD DURING EXTRACORPOREAL CIRCULATION IN MAN

BIOCHEMICAL STUDIES OF MYOCARDIUM AND BLOOD DURING EXTRACORPOREAL CIRCULATION IN MAN

Abstract only We have studied samples of myocardium from 40 patients with congenital heart disease for catecholamine, histamine, and glycogen content. Blood samples obtained before, during, and after cardiopulmonary bypass in 53 patients were assayed for total protein, osmolality, catecholamines, hi...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 1965-04, Vol.31 (4s1), p.SUPPL 1:144-SUPPL 1:149
Hauptverfasser: COOPER, T, JELLINEK, M, WILLMAN, V L, GANTNER, Jr, G A, HANLON, C R
Format: Artikel
Sprache:eng
Schlagworte:
Biochemical Phenomena
Biochemistry
Blood
Blood Proteins
Catecholamines
Cholinesterases
Extracorporeal Circulation
Glycogen
Heart
Heart, Artificial
Histamine
Humans
L-Lactate Dehydrogenase
Male
Myocardium
Old Medline
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Zusammenfassung:Abstract only We have studied samples of myocardium from 40 patients with congenital heart disease for catecholamine, histamine, and glycogen content. Blood samples obtained before, during, and after cardiopulmonary bypass in 53 patients were assayed for total protein, osmolality, catecholamines, histamine, lactic acid dehydrogenase activity, and cholinesterase activity. The data show that (1) adequate cardiopulmonary bypass is accompanied by increased sympathetic activity, (2) myocardial damage, indicated by elevated plasma lactic acid dehydrogenase activity, may occur during operation, and (3) depletion of myocardial catecholamine content may be a concomitant of heart disease with chronic congestive failure.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.31.4s1.i-144