1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains

A set of 21 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was evaluated for in vitro antimycobacterial activity against Mycobacterium avium and two strains of M. kansasii. We tried to use the Hansch approach, the Free-Wilson approach and their com...

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Veröffentlicht in:	Folia microbiologica 2005-01, Vol.50 (3), p.195-197
Hauptverfasser:	Waisser, K, Adamec, J, Dolezal, R, Kaustová, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacteria Humans In Vitro Techniques Microbial Sensitivity Tests Microbiology Mycobacterium avium - drug effects Mycobacterium avium - pathogenicity Mycobacterium kansasii - drug effects Mycobacterium kansasii - pathogenicity Pathogens Structure-Activity Relationship Tetrazoles - chemistry Tetrazoles - pharmacology
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Zusammenfassung:	A set of 21 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was evaluated for in vitro antimycobacterial activity against Mycobacterium avium and two strains of M. kansasii. We tried to use the Hansch approach, the Free-Wilson approach and their combination for structure-activity correlation but the calculations were statistically insignificant.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02931565