Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

The anti-inflammatory activity of zerumbone ( 1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. Zerumbone ( 1), a natural cyclic sesquiterpene, isolated from Zingiber zerumbet Smith, produced significant dose-dependent inhibition of paw edema induced by carrageenan and significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test in mice. [Display omitted]